The 34-year-old was part of the Dutch squad that reached the semi-finals of the World Cup in 2014 and the quarter-finals in 2022. "A talented new generation is coming up and it is time to fully focus on my club and my family," Blind said in a message on X.
"It was an honour to wear the Oranje shirt 108 times, for me that is the greatest thing a player can achieve: representing your country," added the defender.
Blind came through the Ajax youth system. In 2014, he transferred to Manchester United during the reign of Dutch coach Louis van Gaal.
His stint at United brought success in the FA Cup and the Europa League but he went back to Ajax in 2018 and won three Eredivisie trophies. In January 2023, he signed for Bundesliga giants Bayern Munich, before moving to Girona in La Liga.