Atalanta captain Papu Gomez fired the hosts ahead on 10 minutes when he gathered the ball on the left wing and drifted into the area before blasting beyond Gianluigi Donnarumma.

Mario Pasalic, on loan from Chelsea, added a second on the hour in Bergamo when he flicked in a flashing drive from Robin Gosens.

Ilicic made it 3-0 with a clinical finish after a Pasalic assist and the Slovenian attacker struck again on 72 minutes when he curled a majestic strike into the top corner from 20 yards.

Luis Muriel then replaced Ilicic and scored with minutes of his introduction, pouncing on hesitancy from Donnarumma to round out a resounding victory.

Atalanta have scored a league-best 43 goals this season.

The Bergamo side are competing in the Champions League for the first time this season and were drawn against Valencia in the last 16 after scraping through the group stage.