Mbappe, who also scored in a draw against champions Paris Saint-Germain in October, netted the winner with the first clear scoring chance. Latching onto a ball over the top from Nabil Bentaleb, Mbappe capitalized after Marseille goalkeeper Geronimo Rulli's rash dash to the box's edge after ten minutes.
Lille had the better of the opening stages but were indebted to goalkeeper Berke Ozer for a pair of stunning saves in the second half to deny English forward Mason Greenwood and midfielder Geoffrey Kondogbia.
Marseille coach Roberto De Zerbi was dumbfounded by his team's poor performance. "I am really annoyed, I wasn't expecting a match like that," he said. He lamented losing second balls, failing to string three passes together, and lacking aggression. "From the first minute to the last, we played passively." The defeat leaves Marseille third, ahead of Lille on goal difference and behind league leaders Lens and PSG.