While talk over Luciano Spalletti's future and the Scudetto celebrations were already winding down, the Nerazzurri shuffled their lineup between their victory over Milan in the Champions League semifinals and their matchup with Fiorentina in the Coppa Italia Final on Wednesday. Injured players were Milan Skriniar, Chucky Lozano, Henrikh Mkhitaryan, and Valentin Carboni, who was competing in the Under-20 World Cup. Inter was the only team Napoli had not defeated this season, and they dealt Napoli its first Serie A loss in January.
Victor Osimhen's header went directly at Andre Onana, but Napoli were incensed because Roberto Gagliardini should have received a second caution for his late challenge on Kvicha Kvaratskhelia after only 23 minutes. Additionally, Osimhen's claims for a penalty following a small shirt-tug by Alessandro Bastoni were denied. An acrobatic overhead kick by Osimhen then sailed wide, and Zielinski subsequently missed a free kick.