Alieu Fadera's close-range tap-in gave Sassuolo their first points of the season, helping them upset a Lazio team that was suffering from an increasing number of injuries. The hosts had a terrible start here, losing both games against Cremonese and Napoli, but they did win Serie B last season. Ismael Kone had returned from suspension, while Laurs Skjellerup remained sidelined. Despite missing Matias Vecino, Manuel Lazzari, and Patric, the Aquile crushed Verona 4-0. Nicolò Rovella and Mattia Zaccagni started despite having muscular problems while playing for their country, while Alessio Romagnoli made his season debut following a two-match suspension.

There was controversy after 25 minutes when the referee flashed a straight red card for Aster Vranckx as he went into a high tackle on Rovella in the centre-circle. However, following a VAR On-Field Review, he downgraded his decision to a yellow card, as it was on the foot and certainly not the ankle.