Mateo Retegui, Junior Messias, Kevin Strootman, Filip Jagiello, and suspended custodian Josep Martinez were left out, while Alberto Gilardino and Ruslan Malinovskyi were reunited with their previous coaches. With El Bilal Toure, La Dea lost Teun Koopmeiners to injury, and Sead Kolasinac also wasn't fully well. In the first 90 seconds, Scamacca put goalie Nicola Leali to the test, while Malinovskyi's free kick went over the wall and Caleb Ekuban missed the target.
Leali parried Lookman's effort at the near post and finger-tipped Marten de Roon's shot over the bar. When Aleksei Miranchuk entered the game in the second half, he had an instant effect. His pull-back from the byline led to a Scamacca back-heel flick, but Leali's stop was even more remarkable. Giorgio Scalvini's header from eight yards later deflected against the inside of the near post.