The France midfielder trudged out of Chelsea's 3-0 win over Watford, and could now sit out Tuesday's trip to Selhurst Park.
Olivier Giroud, Willian and Ross Barkley all found the net as the Blues eased past the Hornets, to jump back into the league's top four and shake off Wednesday's frustrating 3-2 loss at West Ham.
Kanté 's injury proved perhaps the sole blow in Chelsea's comfortable Saturday night victory at Stamford Bridge, leaving Lampard sweating on the 29-year-old's fitness.
"N'Golo Kanté has a small hamstring injury, we hope it is small, that's what I've been told so far," said Lampard.
"But I'm guessing it will be a problem for Palace on Tuesday." Italy midfielder Jorginho has yet to feature for Chelsea since the league's restart, but Lampard insisted the former Napoli man remains in his thoughts.