"Following the demands of the sports world and knowing that the ban on sporting events open to the public remains in force in six regions of northern Italy, we have agreed to the holding of matches behind closed doors," said Sports Minister Vincenzo Spadafora after a meeting of the Council of Ministers.
Inter Milan themselves announced their Europa League match with Ludogorets on Thursday would be played with no fans present.
"In agreement with UEFA, the Lombardy regional health authorities and Milan city council, our return game with Ludogorets will be played behind closed doors," an Inter statement said.
The sports minister did not specify which Serie A matches at the weekend would be included in the ban.
There are six games in the regions he mentioned, including the clash on Sunday evening between leader Juventus and third-place Inter.