Three stunning individual goals from Paulo Dybala, Cristiano Ronaldo and Douglas Costa downed relegation-threatened Genoa and kept Maurizio Sarri on course to deliver Juve's ninth straight league title in his first season as coach.
Andrea Pinamonti pulled one back with 14 minutes left for the struggling hosts, who stay just one point above the drop zone and third-from-bottom Lecce, who host Genoa's local rivals Sampdoria on Wednesday.
Pinamonti's strike was the first goal Juve have conceded since losing at Lyon in late February, but it wasn't enough to stop the champions from cruising to their sixth straight league win.
"It was a good team effort and we scored three brilliant goals," said Sarri. "The team have recovered well after the strange disappointment of losing the Italian Cup final, it was only a matter of time."