Florenzi replaced Leonardo Spinazzola at right-back during Roma’s 3-0 victory over Brescia at the weekend.
However, Corriere dello Sport reports he strained his right thigh flexor and is therefore touch-and-go to face Basaksehir.
Spinazzola, on the other hand, has regained full fitness and can slot straight back into the side. Javier Pastore, meanwhile, again trained alone today as he continues to shake off a hip problem.