Germany host Iceland in Duisburg on Thursday before facing Romania away on Sunday, then play North Macedonia three days later back in Duisburg.
"We want to start the European championship year with an exclamation mark and please our fans again," Loew said after naming teenagers Jamal Musiala, 18, and Florian Wirtz, 17, in his squad.
"Our ambition and goal is to get ourselves into a good starting position with three wins."
A fortnight ago, Loew announced he will step down, after 15 years in charge, following the European championships, due to take place from June 11-July 11.