The 42-year-old goalkeeper Buffon passed the previous record of 647 appearances he jointly held with AC Milan great Paolo Maldini as he started the game at the Allianz Stadium.
"Maybe... He definitely won't beat the record for scoring goals, though," coach Maurizio Sarri told Sky Sport Italia when asked if Buffon could still play the 35 games he needs to equal Alessandro Del Piero's overall record amount of Juventus appearances.
Cristiano Ronaldo was among the scorers, becoming the first Juve player to score 25 Serie A goals in a season in 59 years, as Sarri's men moved further clear of second-placed Lazio, which were defeated by in-form AC Milan later.
"We were a bit chaotic at the start of the second half, but when fatigue set in, that's when our quality emerged," added Sarri.