Hertha moved up to 10th place after the opening match of the second round of games since the Bundesliga restarted last week under strict coronavirus measures thanks to second-half goals from Vedad Ibisevic, Dodi Lukebakio, Matheus Cunha and Dedryck Boyata.
"It would have been fantastic if we could have played a game like that in front of 75,000 spectators. But I hope that the fans at least had fun in front of their TVs," said Hertha coach Bruno Labbadia.
"In the first half we played very well against well-organised opponents. I had to make that clear to my team at half-time because they were feeling a bit negative. By the end we were happy because these were important points in the relegation battle."
A minute silence was held before kick-off at the eerily quiet ground in the German capital in remembrance of all victims of COVID-19.