The Liverpool captain made his injury return for England on Monday night after suffering a hamstring problem against Newcastle United in late August.
Jürgen Klopp's side will return to domestic action on Saturday against the Seagulls after an extended break in matches following Chelsea's postponement ahead of September's international games.
Henderson hopes the Reds can build on their late win over AFC Ajax in the final Champions League match, aiming to help Liverpool get into action ahead of the winter hiatus for the FIFA World Cup.
Number 14 told The Mirror: "This is a great game for us. It will be difficult too because Brighton is a very good club, as they have shown throughout the start of the season. Graham Potter has done an amazing job there and they have great players".