In the first leg of the round-of-32, Wolves beat Espanyol 4-0, Eintracht beat Salzburg 4-1 and Rangers beat Braga 3-2 at Ibrox.
Arsenal won 1-0 at Olympiakos and, in early games, Manchester United drew 1-1 away to Club Brugge and Celtic's visit to Copenhagen finished with the same score.
In a battle between two European heavyweights Bayer Leverkusen held off Porto 2-1.
Jota, who hit three in the last pool game in November, struck the first from close range, the second from a narrow angle and the third from outside the area. Ruben Neves hit a typically spectacular volley and Wolves crushed the club struggling at the bottom of La Liga.
In Frankfurt, Kamada, a 23-year-old Japanese midfielder, hit the first after 12 minutes. Two minutes before the break he broke from the halfway line to score a second. He added a third with a header in the 53rd minute.