"It is [a huge blow] but we have to move forward," he said after confirming the extent of the setback for the Belgium international.
"He has an important part of the season out and we have to find a solution."
Handily for Guardiola, having the likes of Bernardo Silva, Ilkay Gundogan and Phil Foden to choose from within his creative department means such solutions are - in theory at least - close at hand.
Here, we will examine how well equipped City are to face a run of fixtures including games against Liverpool, Tottenham, Arsenal, Borussia Monchengladbach and possibly Manchester United without their star midfielder.