After Harry Kane scored the only goal in Bayern Munich's 1-0 victory over Cologne, Xabi Alonso's men started the match in second place but won comfortably and will end the weekend two clear atop the table. The win continues Leverkusen's stunning run this season, with Alonso's side having won 17 and drawn one of their 18 fixtures in all competitions.
Leverkusen's high-energy attack forced Bremen midfielder Olivier Deman into conceding an early own goal. Frimpong added a second just before half-time.
Grimaldo sealed the result with a third with 15 minutes remaining for his fourth goal in his past three league matches. Leverkusen midfielder Granit Xhaka told 'Sky Germany' "we are in a great dynamic. We are playing well and everything is going in the right direction at the moment."