The experienced pair have not played for their country since being told by Low in March 2019 that they, along with Jerome Boateng, had no future with the national team.
Low's decision to focus on younger talent has not always paid dividends, though, and last November's 6-0 demolition by Spain prompted loud calls from the likes of Mesut Ozil to bring those senior players back into the fold.
A report in Kicker claimed Muller and Hummels are set to be handed places in Low's Euro 2020 squad, which will be his last major tournament in charge before he steps down after 15 years in the role.
While insisting he has made no promises over either player's future, Low did admit the impact of the coronavirus pandemic could mean his planned "upheaval" of the team may have to be put on hold.