A few hours after Messi's old side Barcelona take on Real Madrid in the Clasico, the Argentinian will take to the field at the Velodrome in the fixture known as "Le Classique".
It is a rivalry that grew in the early 1990s, when Marseille were the dominant force in French football and, for a short while, in Europe.
These days Qatar-owned PSG reign supreme in France, even if they missed out on the Ligue 1 title last season to Lille and their performances in this campaign have not always convinced.
They have won seven of the last eight meetings of the clubs across all competitions and have lost just once to OM in the last decade.