The stadium previously hosted the 1986 European Cup final between Barcelona and Steaua București, when the Romanian club delivered one of the biggest shocks in the tournament’s history with a penalty shootout victory.
The stadium now holds 43,883 spectators and its host club have won the Europa League competition a record five times, with the news confirmed on Tuesday.
The city of Seville hosted the 2003 UEFA Cup final, when FC Porto defeated Glasgow Celtic 3-2 in La Cartuja – a stadium without a host club.
This season's UEFA Europa League decider will be held in the Polish Gdansk Stadium in Gdansk, on Wednesday 27 May.
The Spanish National Team have never lost a match in the Ramón Sánchez Pizjuán, since their first fixture in 1961 to their latest in 2015. In total, the team has played 25 matches at the stadium, with a record of 20 wins and five draws.