Ahly are away to Simba of Tanzania in the opening match on 20th October and, if successful in the two-leg quarter-final, will meet Petro Luanda of Angola or Mamelodi Sundowns of South Africa in the semi-finals.
Should Wydad overcome Enyimba of Nigeria at the last-eight stage, they will face TP Mazembe from the Democratic Republic of Congo or Esperance of Tunisia for a place in the final.
Matches between Ahly and Wydad are among the most anticipated in the continent with the Cairo outfit winning 2-1 and home and drawing 1-1 in the last Champions League final. Each tie will be played over two legs with the final scheduled for November 5 and 11.
The competition was called the Africa Super League when launched in Tanzania last year, but CAF president Patrice Motsepe said the name was changed after advice from undisclosed Europeans.