Antoine Kombouare's side booked a place in the April 29 showpiece at the Stade de France against either Toulouse or second-tier Annecy. Lyon are still waiting for a first appearance in the final since winning the competition in 2012, after failing to back up last weekend's Ligue 1 victory over Paris Saint-Germain.
Nantes, whose Cup triumph last season was their first major trophy since winning the league in 2001, have a golden chance of a successful defence. Record 14-time winners PSG suffered a second straight early exit in the last 16 to Marseille, who were then dumped out by Annecy. Nantes started brightly on Wednesday as they continued their bid for a fifth French Cup.