El Tri were left frustrated by a stubborn Soca Warriors backline, led brilliantly by goalkeeper Marvin Phillip who made numerous strong saves and was named Man of the Match.
The holders thought they had found a winner in second-half stoppage-time when Rogelio Funes Mori tucked in Jesus Gallardo's low cutback but the latter was ruled marginally offside.
Mexico dominated proceedings, with 30 shots to four, including seven on target, along with 83 per cent possession yet they were unable to capitalise.
Hirving Lozano had to be replaced early in the first half with a suspected concussion and neck injury, before Jesus Corona tested Phillip and Hector Herrera shot wide from distance a few after.