Stefano Pioli's side are two points ahead of reigning champions Inter Milan and only need to draw to claim their first league crown since 2011, and they look almost guaranteed to do so after a hugely impressive run-in.
Consecutive wins over tricky opponents Lazio, Fiorentina and Verona were followed up by last weekend's 2-0 home victory over Atalanta, after which a packed San Siro celebrated as though the title was already theirs.
Pioli has an almost full squad to pick from against a team which beat Milan 3-1 earlier in the season and will have the backing of an estimated 18,000 fans at the Mapei Stadium in Reggio Emilia for a title party which will then spill back into Milan.