Pedri and Bryan Gil are among four players to have been called up to the Spain squad for the first time for March's World Cup qualifiers.
Barcelona midfielder Pedri and winger Gil, on loan at Eibar from Sevilla, have been rewarded for their performances in breakthrough seasons in LaLiga.
Head coach Luis Enrique has also called up Brighton and Hove Albion goalkeeper Robert Sanchez and Sporting CP defender Pedro Porro for the first time.
There is a return for Barca left-back Jordi Alba, who last played for La Roja in September 2019 in a Euro 2020 qualifying win over Romania.
Leeds United's Diego Llorente and Liverpool midfielder Thiago Alcantara are also back in the 24-man squad.