Luke Shaw, Anthony Martial, Diogo Dalot and Eric Bailly will also definitely miss the today clash with the Foxes, while Jesse Lingard and Aaron Wan-Bissaka are both doubtful after withdrawing from England’s Euro 2020 qualifiers against Bulgaria and Kosovo.
Pogba twisted his ankle in the 1-1 draw at Southampton two weeks ago and did not play for France in their two matches during the international break, with the midfielder expected to return for the match at West Ham on 22 September.
Shaw (hamstring) and Martial (thigh) have still not recovered from the injuries sustained in the 2-1 defeat to Crystal Palace on 24 August, while Dalot (hip) and Bailly (knee) are longer-term injuries.
"The treatment room has been busy and it still is," said Solskjaer. "We don’t really know who is going to be available".