The defending champions climbed above Girona and have 57 points from 26 games.
Joao Felix and Raphinha missed the midweek Champions League 1-1 draw at Napoli and their return paid dividends.
Brazilian forward Raphinha broke the deadlock on 20 minutes latching onto a deep pass with a well-timed run and slick shot into the bottom corner.
Raphinha was involved in the build-up to the second goal as Felix doubled the lead with a far post tap in after 53 minutes.
Dutch midfielder Frenkie De Jong did make it 3-0 just after the hour with a well struck shot from outside the box before Fermin Lopez tapped home a rebound in time added on.
A minute's silence was observed before the match as a mark of respect following a fire tragedy at a 14-storey apartment block which killed 10 people in Valencia. The Liga game between Granada and Valencia was postponed.