Jose Mourinho's side beat Feyenoord in the final of the inaugural Europa Conference League in Tirana in 2022, and then came out on top in the quarter-finals of last season's Europa League, en route to losing the final on penalties to Sevilla.
The knockout round play-offs see the teams who came third in their Champions League groups face off against the runners-up from the Europa League group stage. The winners will advance to the last 16, where they will join the eight group winners.
Reigning Dutch title-holders Feyenoord dropped out of the Champions League after coming third in a group behind Atletico Madrid and Lazio.