The Asian Football Confederation (AFC) said the AFC Cup match between North Korea's 4.25 SC and Al Ahed from Lebanon would take place in the Malaysian capital Kuala Lumpur on November 4.
It came just days after the AFC announced the final of Asia's second-tier club competition was being shifted from Pyongyang to Shanghai, and that it would be played on November 2.
The football body gave no reason for changing the venue of the match again but apologised for "the unavoidable inconvenience".
Announcing the first change of venue earlier this week, the AFC did not mention the World Cup qualifier in Pyongyang but said that commercial partners had warned of challenges in broadcasting the game.