After last weekend's 1-1 draw against Liverpool, Pochettino's side wasted a lively performance as they paid the price for sloppy defending and wasteful finishing at the London Stadium. Antonio blasted West Ham's decisive second goal after half-time and Lucas Paqueta added a late penalty to leave Pochettino still waiting for his first Premier League win since taking charge in the close-season.
Chelsea teenager Carney Chukwuemeka had scored an eye-catching first half equaliser to cancel Nayef Aguerd's early opener for West Ham. But the turning point came when Fernandez's penalty was saved by Alphonse Areola just before the break. Antonio netted soon after the interval and Chelsea couldn't respond despite Aguerd's dismissal for a second booking midway through the half.
Paqueta, reportedly the subject of an FA probe into betting breaches, applied the knockout blow in the final seconds.