Level at 1-1 after the last-16 first leg in the Netherlands, Sancho wasted no time in putting Dortmund ahead at the Westfalenstadion with a low shot from outside the area - his first Champions League goal since November 2021. Dortmund were shaky despite the early lead and needed a fair share of luck and some poor PSV finishing to progress, with Hirving Lozano's 53rd-minute effort hitting the post.
Malen went close to score before the interval, twice firing wide when he should have at least hit the target. The visitors were much improved after the break.
PSV's best opportunity to force extra time fell to De Jong in the fourth minute of added time, but the Dutch striker blazed over unmarked from only 10 yards out. Reus quickly made him pay, racing onto a loose ball and slotting calmly past Benitez to spark wild home celebrations.