Jurgen Klopp's side are one of four British teams still alive in the competition and hoping to go all the way to this season's final, in Dublin on May 22nd.
Sparta are top of the Czech league and have had some fine results in Europe this season, qualifying from their group ahead of Real Betis and then eliminating Galatasaray in the knockout round play-offs.
Having won the League Cup, the Reds are top of the Premier League and also through to the last eight of the FA Cup. The biggest danger for them heading to the Stadion Letna in Prague is that their minds may be on Sunday's huge meeting with Manchester City.
They could yet cross paths with Leverkusen, who are enjoying a stunning campaign under former Liverpool midfielder Alonso. Unbeaten all season, they are 10 points clear at the top of the Bundesliga with 10 games left.