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The hosts took the lead shortly after half-time, but Hojlund levelled on 62 minutes, when the Danish striker tapped in Amad Diallo's deflected shot. Two minutes from time, he beat Plzen goalkeeper Martin Jedlicka again with a clinical finish after United captain Bruno Fernandes had found him unmarked inside the box with a free-kick.
Matej Vydra, a former Watford, West Brom, Reading, Derby and Burnley forward, had formerly opened the scoring for the hosts with a close-range finish three minutes after half-time. Pavel Sulc found Vydra facing an empty net after he had intercepted United goalkeeper Andre Onana's pass inside the box.
The goal was a wake-up call for United manager Ruben Amorim, who made three replacements in its wake, including Hojlund. The former Sporting boss replaced the sacked Eric ten Hag in November, but the chilly evening in Plzen showed United still have to work.
