Cristiano Ronaldo also features in the Portuguese side that booked their place at the championships when they beat Slovakia 3-2 in October.
With coach Roberto Martinez now able to use the final two matches as preparation ahead of the tournament in Germany next summer, Pepe returns after a spell out with injury. "The objective for him and for us is to be fit for these matches," Martinez told a press conference.
The 40-year-old, who made his international debut back in 2007, "is an exemplary professional" with "a great deal of experience", said Martinez. The 26-man squad also features the return of Sporting Braga striker Bruma.
With eight points, Portugal lead the Group J standings. The Portuguese team will travel to Vaduz to take on Liechtenstein on November 16, before returning to Lisbon to play Iceland on November 19 at the Alvalade stadium.