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A statement on United's website added Fred would fly to Istanbul for a medical on Saturday, with the deal also subject to the midfielder "agreeing personal terms and receiving international clearance to process the move".
United paid tribute to Fred by saying: "The 30-year-old leaves so many positive memories from his time at Old Trafford, where he has been a hugely popular individual, both as a person and as a player.
"Everybody at the club would like to wish the very best of luck to Fred for the future, as we await confirmation that the deal is completed."
No fee has been disclosed, but the 'Manchester Evening News' reported United had accepted a 15 million euros (£13 million) fee from Fenerbahce for the Brazilian, whose last appearance for the Red Devils was in the FA Cup final defeat by local rivals Manchester City in June.
