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Gladbach sprung a surprise by making it out of their group behind Real Madrid, having qualified for the knockout stages by finishing above Shakhtar Donetsk and Inter.
Now the Bundesliga side face the runaway Premier League leaders without the benefit of playing at home. Due to travel restrictions in Germany amid the coronavirus pandemic, the first leg takes place on Wednesday in the Hungarian capital of Budapest.
Rose – who is leaving at the end of the season to take charge at domestic rivals Borussia Dortmund – acknowledges the underdogs will have to defend well to keep Pep Guardiola's in-form side at bay, though he also stressed the importance of being brave in possession if they are to have any chance of springing a huge surprise.
"When you're Borussia Monchengladbach and you're playing a Champions League last-16 match against Manchester City, you can't really lose," Rose told the media.
