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'La Roja' face Scotland on 12th October and Norway on 15th October as they bid to secure qualification for the tournament in Germany next year.
Fran Garcia was part of the squad which triumphed in the Netherlands this year as Spain won the Nations League but has not yet made his debut, while Sancet is included for the first time.
The 23-year-old midfielder has been sent off twice this season in six La Liga appearances for Athletic, scoring one goal against Alaves. Garcia has had a mixed start at Madrid following his summer move from Rayo Vallecano, with some strong contributions in attack but issues defensively.
"[Sancet] gives us a lot, plays between the lines well, gets into the box, has fantastic potential and fits our idea, we trust him. Fran is a player who will have a big career," said De la Fuente.
